Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
نویسندگان
چکیده
منابع مشابه
Antagonism of 8-OH-DPAT-induced behaviour in rats.
Selective activation of the 5-HT1A receptor induces lower lip retraction (LLR) in rats. 8-Hydroxy-dipropylamino tetralin (8-OH-DPAT)-induced LLR could not be antagonised by the 5-HT antagonists methysergide, metergoline or mesulergine. In fact, some 5-HT antagonists induced LLR. However, 8-OH-DPAT-induced LLR could be antagonised by pindolol, spiperone, spiroxatrine and NAN-190, but not by the ...
متن کاملThe Lonely Mouse – Single Housing Affects Serotonergic Signaling Integrity Measured by 8-OH-DPAT-Induced Hypothermia in Male Mice
Male BALB/c mice single-housed for a period of three weeks were found to respond with a more marked hypothermia to a challenge with a selective serotonergic agonist (8-OH-DPAT) than their group-housed counterparts. This effect of single housing was verified by screening a genetically heterogeneous population of male mice on a C57BL/6 background from a breeding colony. Enhanced activity of the i...
متن کامل8-OH-DPAT (5-HT1A agonist) Attenuates 6-Hydroxy- dopamine-induced catalepsy and Modulates Inflammatory Cytokines in Rats
Objective(s): Neuroinflammation in Parkinson disease (PD) is associated with glial cells activation and production of different inflammatory cytokines. In this study, we investigated the effect of chronic administration of 8-OH-DPAT on 6-OHDA-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (CSF). Materials and Methods: Catalepsy was induced by un...
متن کاملRepeated imipramine treatment enhances the 7-OH-DPAT-induced hyperactivity in rats: the role of dopamine D2 and D3 receptors.
Previous studies have shown that antidepressant drugs with different pharmacological profiles, administered repeatedly, increase the locomotor hyperactivity induced by various dopaminomimetics, among others by (+/-)7-hydroxydipropylaminotetralin (7-OH-DPAT). Since, according to a recent study, this drug shows a high affinity for not only dopamine D3 but also dopamine D2 receptors, a question ar...
متن کاملModulation of [h]-8-oh-dpat Binding to Rat Brain Membranes by Metal Ions
The binding of [H]-8-OH-DPAT to rat hippocampal and cortical membranes was specific and saturable with Kd = 0.87 ± 0.18 nM and Kd = 2.4 ± 0.9 nM, respectively. Guanine nucleotides decreased the [H]-8-OH-DPAT binding affinity without significant influence on the number of binding sites. The radioligand binding affinity was only slightly affected by the pH in the interval from 6 to 9. The 5-HT1A ...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2003
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.93.259